PathwayLinker: Linking proteins to signaling pathways for the design and evaluation of experiments

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PathwayLinker

Link proteins to signaling pathways · Design & evaluate experiments

Search: Organism & proteins

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Select interaction types

Select signaling pathways

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Welcome. PathwayLinker identifies and visualizes the first neighbor interactor network of the queried proteins, analyzes the signaling pathway memberships of the proteins in this subnet, and provides links to further online resources.

Organism

C. elegans

D. melanogaster

H. sapiens

Search terms

Examples

with UniProt

Biomedical research often focuses on altering the functions of selected proteins. These changes can unexpectedly perturb signaling pathways and non-specifically affect several cellular processes. PathwayLinker can assist experimental work by linking the queried proteins to signaling pathways through protein-protein and/or genetic interactions.

If you find PathwayLinker useful for your work, interactively or the API, then please cite our work. Thank you.

Linking proteins to signaling pathways for experiment design and evaluation
Farkas I J, Szántó-Várnagy Á, Korcsmáros T
PLoS ONE 7, e36202 (2012)
Abstract · Full Text PDF · PathwayLinker.org

Support: European Research Council Grants FP6-518230 and TAMOP 4.2.1./B-09/1/KMR-2010-0003; Hungarian Scientific Research Fund Grant K75334; Hungarian Research and Technology Office Grant 5LET-08-2-2009-0041; UCSF Center for Systems and Synthetic Biology.

Search terms	You can enter names and identifiers of genes and proteins (search terms). PathwayLinker maps these to UniProt primary accessions with the UniProt API, which recognizes the following types of gene/protein identifiers. In addition, for H. sapiens you can search for drug targets with the DrugBank IDs, Brand names and Generic names of drugs/compounds. Separate search terms with commas.
Quick search	For each search term only one (the most relevant) search hit is selected. For a manual selection of one or more search hits please use the Advanced search. All available interaction types and signaling pathway sources are used.
Advanced search	You can manually select proteins for each search term separately. Search terms with 0 or 1 UniProt hit (protein) are not shown. If there is 1 hit, then it is automatically selected for the given search term. You can change all search terms and selections (including those for search terms with 0 or 1 hit) from the selection summary page. You can manually select interaction types and signaling pathway sources.

Quick search